[TMIC] Archive of Lupus-R Mailing List: MED: Lupus of the spine II

Barbara Dusel (barbd(AT)adept.net)
Fri, 02 Apr 1999 22:15:34 -0500

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I put that word in a search engine and got this site
which lists that as a cure in one of the cases. It was interesting.
See what you guys think. Talks about lupus and TM...

http://www.hamline.edu/lupus/rarchive/0080.html

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0080.html"

Archive of Lupus-R Mailing List: MED: Lupus of the spine II

MED: Lupus of the spine II

Robinzon Boaz (robinzon(AT)agri.huji.ac.il)
Wed, 1 Jul 1998 09:09:27 -0500 (CDT)

Record 21 of 58 - MEDLINE (R) Advanced
TI: Spinal cord infarction associated with primary antiphospholipid syndrome in a young child. Case report.
AU: Hasegawa-M; Yamashita-J; Yamashima-T; Ikeda-K; Fujishima-Y; Yamazaki-M
SO: J-Neurosurg. 1993 Sep; 79(3): 446-50
LA: ENGLISH
AB: Antiphospholipid antibodies have been reported to occur in ischemic stroke patients, but there have been no previous reports linking these antibodies to spinal cord infarction. A case of spinal cord infarction associated with primary antiphospholipid syndrome in a 6-year-old boy is reported. Magnetic resonance imaging clearly demonstrated marked swelling of the thoracolumbar spinal cord with gadolinium-diethylenetriamine pentaacetic acid enhancement at an acute stage, followed later by cord atrophy. Serological study disclosed positive lupus anticoagulant and immunoglobulin G anticardiolipin antibody. It is suggested that the role of antiphospholipid antibodies as an etiological factor for spinal cord ischemia should be recognized among causes that might have been categorized as either spontaneous spinal cord infarction or myelitis.
Record 22 of 58 - MEDLINE (R) Advanced
TI: Myelitis and toxic, inflammatory, and infectious disorders.
AU: Corboy-JR; Price-RW
SO: Curr-Opin-Neurol-Neurosurg. 1993 Aug; 6(4): 564-70
LA: ENGLISH
AB: Spinal epidural abscess is a rare infection that is usually treated with surgery and antibiotics. A small number of patients have been treated with medical therapy alone. We review several recent series of spinal epidural abscess and discuss the controversy surrounding the use of medical therapy alone. We also review recent clinical and pathogenetic data about human T-lymphotropic virus type 1 infection. The role of magnetic resonance imaging in the diagnosis of intramedullary spinal cord abscess, and methylprednisolone and cyclophosphamide treatment of transverse myelitis in systemic lupus erythematosus are also discussed briefly.
Record 23 of 58 - MEDLINE (R) Advanced
TI: Transverse myelitis complicating systemic lupus erythematosus: treatment including hydroxychloroquine. Case report.
AU: Klaiman-MD; Miller-SD
SO: Am-J-Phys-Med-Rehabil. 1993 Jun; 72(3): 158-61
LA: ENGLISH
AB: Transverse myelitis has been cited as a rare and unusual complication of systemic lupus erythematosus (SLE). A review of the literature reveals only 10 cases of transverse myelitis as the initial presentation of SLE, and only one with reported benefits from antimalarial therapy. The case of a 30-year-old woman is reviewed. She presented to the emergency room with complaints of hypogastric and low back pain. The ensuing course was one of frank urinary retention and rapidly progressing quadriparesis. Magnetic resonance imaging of the spine revealed marked edema of the cervical and thoracic spine. A diagnosis of SLE was based on positive antinuclear antibodies and leukopenia. The patient was treated with high dose methylprednisolone, plasmapheresis and pulse cyclophosphamide for 3 months. Subsequently, treatment was begun with hydroxychloroquine, and significant improvement in her neurologic and functional status was achieved after 1 month of therapy. Ten months after her onset of symptoms, the patient suffered an acute exacerbation of paraparesis and urinary retention. Again, she improved clinically after high dose methylprednisolone and pulse cyclophosphamide for 1 month. Hydroxychloroquine was continued throughout the duration of therapy.
Record 24 of 58 - MEDLINE (R) Advanced
TI: Spinal epidural hematoma in a patient with lupus coagulopathy: MR findings.
AU: Mohazab-HR; Langer-B; Spigos-D
SO: AJR-Am-J-Roentgenol. 1993 Apr; 160(4): 853-4
LA: ENGLISH
Record 25 of 58 - MEDLINE (R) Advanced
TI: [Acute transverse myelitis and primary antiphospholipid syndrome]
AU: Sebastian-de-la-Cruz-F; Romero-Ganuza-FJ; la-Banda-Brusi-F; Arzoz-Lezaun-T
SO: Med-Clin-Barc. 1992 Sep 26; 99(9): 342-4
LA: SPANISH; NON-ENGLISH
AB: The case of a 39 years old woman with acute transverse myelitis manifested as a syndrome of the anterior spinal artery is presented. Etiologic investigation diagnosed a primary antiphospholipid syndrome because of the finding of significantly high titers of anticardiolipin antibodies discarding the presence of systemic lupus erythematosus for the lack of sufficient diagnostic criteria. The association between both clinical pictures is infrequent.
Record 26 of 58 - MEDLINE (R) Advanced
TI: [Transverse myelopathy in a patient with systemic lupus erythematosus associated with positive anticardiolipin antibody--a case report]
AU: Ito-H; Nagasato-K; Nakamura-T; Tsujihata-M; Nagataki-S
SO: Rinsho-Shinkeigaku. 1992 Jun; 32(6): 639-41
LA: JAPANESE; NON-ENGLISH
AB: A 52-year-old woman who developed acute transverse myelopathy following systemic lupus erythematosus (SLE) was reported. At the age of 46, she was diagnosed as having atypical psychosis. Neurological examination revealed mild depressive state, paraparesis, diffuse hyperreflexia, hypesthesia below the breasts, and urinary disturbance. Gait was slightly ataxic and Romberg sign was positive. Laboratory study disclosed lymphocytopenia, positive antinuclear antigen, false positive Venereal Disease Research Laboratories flocculation test and prolonged activated partial thromboplastin time. IgG anticardiolipin antibody (aCLA) was positive, whereas IgM aCLA was negative. Cerebrospinal fluid was normal except the elevation of %IgG. Nerve conduction studies were normal and no abnormality was detected in the brain and spinal cord by MRI and CT. We treated her by two series of steroid pulse therapy, which resulted in marked improvement of symptoms and disappearance of aCLA. Before and after the pulse therapy, symptoms were fluctuated in parallel with the levels of aCLA. These findings suggest the relation of aCLA to the transverse myelopathy in SLE. This is the first case report of a good prognosis of myelopathy in a SLE patient who was treated by steroid pulse therapy with the aim of disappearance of aCLA.
Record 27 of 58 - MEDLINE (R) Advanced
TI: Lupus-related myelopathy: report of three cases and review of the literature.
AU: Provenzale-J; Bouldin-TW
SO: J-Neurol-Neurosurg-Psychiatry. 1992 Sep; 55(9): 830-5
LA: ENGLISH
AB: Transverse myelopathy is an uncommon complication of systemic lupus erythematosus (SLE). Three patients with SLE are reported who developed transverse myelopathy, including the neuropathological findings in one patient on whom necropsy was performed. Paraparesis was present in all three cases, but definite sensory changes were present in only one patient. In two patients, the CSF findings were remarkable for elevated protein and depressed glucose concentrations. Microscopic examination of the brain demonstrated small, scattered foci of recent necrosis consistent with microinfarctions. Striking abnormalities were found in the spinal cord at all levels, including multiple foci of vacuolar spongy degeneration in the peripheral white matter, as well as ballooning of myelin sheaths, swollen axons, myelin pallor, and loss of glial nuclei. The pathological findings in previously reported cases of SLE-related transverse myelopathy are reviewed, and the possible pathogenesis of the findings in our case are discussed.
Record 28 of 58 - MEDLINE (R) Advanced
TI: Transverse myelitis in systemic lupus erythematosus: two cases with magnetic resonance imaging.
AU: Simeon-Aznar-CP; Tolosa-Vilella-C; Cuenca-Luque-R; Jordana-Comajuncosa-R; Ordi-Ros-J; Bosch-Gil-JA
SO: Br-J-Rheumatol. 1992 Aug; 31(8): 555-8
LA: ENGLISH
AB: Transverse myelitis is one of the most serious neurological complications occurring in the course of systemic lupus erythematosus. We describe two lupus patients, with transverse myelitis, one of whom had associated optic neuritis. In both, magnetic resonance imaging of the spinal cord showed an abnormal signal. In one case a good response to steroid and immunosuppressive therapy was observed; the other case failed to improve despite the therapy applied.
Record 29 of 58 - MEDLINE (R) Advanced
TI: Recovery of anterior spinal artery syndrome in a patient with systemic lupus erythematosus and antiphospholipid antibodies [letter]
AU: Dell'Isola-B; Vidailhet-M; Gatfosse-M; Wechsler-B; Dormont-D; Le-Thi-Hvong-DU; Godeau-P
SO: Br-J-Rheumatol. 1991 Aug; 30(4): 314-5
LA: ENGLISH
Record 30 of 58 - MEDLINE (R) Advanced
TI: A case of systemic lupus erythematosus--its clinical and MRI resemblance to multiple sclerosis.
AU: Moriwaka-F; Tashiro-K; Fukazawa-T; Akino-M; Yasuda-I; Sagawa-A; Hida-K
SO: Jpn-J-Psychiatry-Neurol. 1990 Sep; 44(3): 601-5
LA: ENGLISH
AB: We documented a case of systemic lupus erythematosus with clinical features of multiple sclerosis who developed transverse myelopathy. Magnetic resonance imaging showed the presence of an abnormal high signal intensity in the gray matter of a swollen spinal cord corresponding to the patient's neurological deficits. After two previous episodes of exacerbation and remission consistent with the clinical diagnosis of multiple sclerosis, right hemiparesis and hemisensory disturbances ensued, then lupus nephritis was confirmed by a renal biopsy.
Record 31 of 58 - MEDLINE (R) Advanced
TI: Acute transverse myelitis in systemic lupus erythematosus: magnetic resonance imaging and review of the literature.
AU: Boumpas-DT; Patronas-NJ; Dalakas-MC; Hakim-CA; Klippel-JH; Balow-JE
SO: J-Rheumatol. 1990 Jan; 17(1): 89-92
LA: ENGLISH
AB: We describe a patient with systemic lupus erythematosus (SLE) who presented with acute transverse myelitis. Magnetic resonance imaging (MRI) of the cervical spine demonstrated increased signal intensity and diffuse edema in the cervical cord. The patient had low titer of IgG antiphospholipid antibodies and hypocomplementemia. Cerebrospinal fluid analysis showed pleocytosis, increased protein and decreased glucose. Clinical improvement of the neurologic impairment was noted after high dose corticosteroids and intravenous bolus cyclophosphamide. A repeat MRI 12 days after the treatment was normal. MRI of the spine can be useful in the diagnosis and followup of patients with SLE presenting with an acute myelopathic syndrome. Early aggressive treatment may contribute to complete recovery of these patients.
Record 32 of 58 - MEDLINE (R) Advanced
TI: Anterior spinal artery syndrome in systemic lupus erythematosus.
AU: Markusse-HM; Haan-J; Tan-WD; Breedveld-FC
SO: Br-J-Rheumatol. 1989 Aug; 28(4): 344-6
LA: ENGLISH
AB: We present a patient with systemic lupus erythematosus who developed an anterior spinal artery syndrome (ASAS) in association with livedo reticularis, leg ulcerations and thrombocytopenia. Low serum titres of anticardiolipin antibodies were detectable throughout the course of this disease. The patient recovered from the first episode of ASAS under corticosteroid treatment but remained paralytic after a second episode. Repeated magnetic resonance imaging of the spinal cord failed to show altered signal intensity.
Record 33 of 58 - MEDLINE (R) Advanced
TI: Peripheral white matter lesions of the spinal cord with changes in small arachnoid arteries in systemic lupus erythematosus.
AU: Nakano-I; Mannen-T; Mizutani-T; Yokohari-R
SO: Clin-Neuropathol. 1989 Mar-Apr; 8(2): 102-8
LA: ENGLISH
AB: The spinal cords of two autopsy cases of systemic lupus erythematosus (SLE) (case 1, 34-year-old woman; case 2, 40-year-old woman) showed lesions restricted to the periphery and frequent changes in small arteries in the spinal subarachnoid space. There had been clinical cord involvement in both cases, for two months (case 1) and six years (case 2) before death, respectively. The spinal cord of case 1 had circumferentially located, multiple, round, spongy, sometimes necrotic, lesions, containing many swollen axons. Even the apparently spared peripheral regions showed moderate axon loss. Observation of serial sections of the cord revealed the direct connection of some occluded subarachnoid small arteries with vessels within the spongy lesions, indicating the responsibility of the vascular changes for the cord lesions. In case 2, the whole length of the spinal cord showed marked axonal loss in the entire circumferential white matter. Groups of old axonal retraction balls and localized spongy changes were occasionally observed at the periphery. The affected peripheral zone coincided with the region supplied by marginal arteries. These observations suggest that primary vascular lesions, followed by secondary degeneration of axons, played fundamental roles in the development of this unique lesion in case 2, and that localized changes such as those observed in case 1 gradually develop into the continuous lesion seen in case 2.
Record 34 of 58 - MEDLINE (R) Advanced
TI: Transverse myelitis occurring during pregnancy in a patient with systemic lupus erythematosus.
AU: Marabani-M; Zoma-A; Hadley-D; Sturrock-RD
SO: Ann-Rheum-Dis. 1989 Feb; 48(2): 160-2
LA: ENGLISH
AB: Myelopathy is a well recognised but infrequent neurological manifestation of systemic lupus erythematosus (SLE). The case of a 27 year old woman with SLE of seven years' duration who developed a spastic paraparesis during her second pregnancy is reported. Magnetic resonance imaging did not show any intrinsic abnormality of the spinal cord. Anticardiolipin antibody was weakly positive and C4 was low. The patient responded dramatically to steroids.
Record 35 of 58 - MEDLINE (R) Advanced
TI: [Transverse myelopathy and Gottron's sign associated with systemic lupus erythematosus in an elderly woman--a case report]
AU: Shimamoto-Y; Shimamoto-H; Nakamura-H
SO: Nippon-Ronen-Igakkai-Zasshi. 1988 May; 25(3): 309-15
LA: JAPANESE; NON-ENGLISH
Record 36 of 58 - MEDLINE (R) Advanced
TI: Transverse myelitis and optic neuritis in systemic lupus erythematosus: a case report with magnetic resonance imaging findings.
AU: Kenik-JG; Krohn-K; Kelly-RB; Bierman-M; Hammeke-MD; Hurley-JA
SO: Arthritis-Rheum. 1987 Aug; 30(8): 947-50
LA: ENGLISH
AB: We describe a patient with systemic lupus erythematosus who developed transverse myelitis and optic neuritis. Magnetic resonance imaging showed the presence of an abnormal signal in a normal-sized spinal cord which corresponded to the patient's neurologic deficit. No abnormality was recognized in either optic nerve. Magnetic resonance may prove to be a useful imaging modality for the diagnosis of a transverse myelopathy in systemic lupus erythematosus.
Record 37 of 58 - MEDLINE (R) Advanced
TI: Neurofilament antibodies in systemic lupus erythematosus.
AU: Kurki-P; Helve-T; Dahl-D; Virtanen-I
SO: J-Rheumatol. 1986 Feb; 13(1): 69-73
LA: ENGLISH
AB: Autoantibodies against neuronal antigens occur in sera of patients with systemic lupus erythematosus (SLE). These antibodies may have significance in the pathogenesis of neurological complications of SLE. However, the neuronal structures containing the corresponding autoantigens are poorly known. In our study we assayed circulating antibodies against defined neuronal components--neurofilaments--by an enzyme-linked immunosorbent assay (ELISA) using purified neurofilament polypeptides as targets. Circulating neurofilament antibodies (anti-NF) of IgG class were detected in 21% of 28 patients with SLE and in 6% of 17 patients with rheumatoid arthritis and in none of the 14 patients with primary sicca syndrome and 40 blood donors. The presence of anti-NF could also be confirmed by the indirect immunofluorescence technique using frozen sections of rat spinal cord. In one serum, anti-NF cross reacted with vimentin type of intermediate filaments. The antibodies bound both to the 70 kilodalton and the 200 kilodalton polypeptides of neurofilaments as judged by the immunoblotting technique. Two of 6 anti-NF positive patients had neurological complications.
Record 38 of 58 - MEDLINE (R) Advanced
TI: [Systemic lupus erythematosus with spinal cord involvement]
AU: Sato-T; Kikuchi-M; Ogino-S; Nagao-M; Nakano-M; Arakawa-M
SO: Ryumachi. 1986 Oct; 26(5): 344-52
LA: JAPANESE; NON-ENGLISH
Record 39 of 58 - MEDLINE (R) Advanced
TI: Treatment of acute myelopathy in systemic lupus erythematosus with plasma exchange and immunosuppression [letter]
AU: Slovick-DI
SO: J-Neurol-Neurosurg-Psychiatry. 1986 Jan; 49(1): 103-5
LA: ENGLISH
Record 40 of 58 - MEDLINE (R) Advanced
TI: Myelopathy as the main presenting feature of systemic lupus erythematosus.
AU: Al-Husaini-A; Jamal-GA
SO: Eur-Neurol. 1985; 24(2): 94-106
LA: ENGLISH
AB: Myelopathy is a rare complication of systemic lupus erythematosus (SLE). Only 34 cases have been fully described in the literature. 5 other cases have been listed among large surveys of SLE patients. It is particularly unusual to find evidence of spinal cord involvement as the presenting feature of the disease. 2 cases are described in which SLE presented as a myelopathy and both made a satisfactory recovery with steroid treatment. The literature concerning SLE-myelopathy is reviewed.

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